5mwa
From Proteopedia
(Difference between revisions)
m (Protected "5mwa" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==human sEH Phosphatase in complex with 3-4-3,4-dichlorophenyl-5-phenyl-1,3-oxazol-2-yl-benzoic-acid== | |
| - | + | <StructureSection load='5mwa' size='340' side='right' caption='[[5mwa]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mwa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MWA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8S9:3-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]benzoic+acid'>8S9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mwa OCA], [http://pdbe.org/5mwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mwa RCSB], [http://www.ebi.ac.uk/pdbsum/5mwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mwa ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chaikuad, A]] | ||
| + | [[Category: Fox, N]] | ||
| + | [[Category: Knapp, S]] | ||
| + | [[Category: Kramer, J S]] | ||
| + | [[Category: Pogoryelov, D]] | ||
| + | [[Category: Proschak, E]] | ||
| + | [[Category: Sorrell, F J]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Human soluble epoxide hydrolase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Magnesium]] | ||
| + | [[Category: Phosphatase]] | ||
| + | [[Category: Seh]] | ||
Revision as of 06:13, 28 February 2018
human sEH Phosphatase in complex with 3-4-3,4-dichlorophenyl-5-phenyl-1,3-oxazol-2-yl-benzoic-acid
| |||||||||||
Categories: Chaikuad, A | Fox, N | Knapp, S | Kramer, J S | Pogoryelov, D | Proschak, E | Sorrell, F J | Complex | Human soluble epoxide hydrolase | Hydrolase | Inhibitor | Magnesium | Phosphatase | Seh
