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5n2m

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'''Unreleased structure'''
 
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The entry 5n2m is ON HOLD
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==Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue==
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<StructureSection load='5n2m' size='340' side='right' caption='[[5n2m]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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Authors: Tallant, C., Slavish, P.J., Siejka, P., Bharatham, N., Shadrick, W.R., Chai, S., Young, B.M., Boyd, V.A., Heroven, C., Wiggers, H.J., Picaud, S., Fedorov, O., Krojer, T., Chen, T., Lee, R.E., Guy, R.K., Shelat, A.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5n2m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2M FirstGlance]. <br>
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Description: Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2m OCA], [http://pdbe.org/5n2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2m RCSB], [http://www.ebi.ac.uk/pdbsum/5n2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bharatham, N]]
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[[Category: Bountra, C]]
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[[Category: Boyd, V A]]
[[Category: Chai, S]]
[[Category: Chai, S]]
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[[Category: Shelat, A.A]]
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[[Category: Chen, T]]
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[[Category: Boyd, V.A]]
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[[Category: Delft, F von]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Edwards, A M]]
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[[Category: Slavish, P.J]]
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[[Category: Fedorov, O]]
[[Category: Fedorov, O]]
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[[Category: Von Delft, F]]
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[[Category: Guy, R K]]
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[[Category: Heroven, C]]
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[[Category: Knapp, S]]
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[[Category: Krojer, T]]
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[[Category: Lee, R E]]
[[Category: Picaud, S]]
[[Category: Picaud, S]]
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[[Category: Shadrick, W.R]]
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[[Category: Structural genomic]]
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[[Category: Shadrick, W R]]
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[[Category: Shelat, A A]]
[[Category: Siejka, P]]
[[Category: Siejka, P]]
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[[Category: Knapp, S]]
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[[Category: Slavish, P J]]
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[[Category: Guy, R.K]]
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[[Category: Edwards, A.M]]
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[[Category: Heroven, C]]
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[[Category: Wiggers, H.J]]
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[[Category: Lee, R.E]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Tallant, C]]
[[Category: Tallant, C]]
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[[Category: Chen, T]]
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[[Category: Wiggers, H J]]
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[[Category: Krojer, T]]
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[[Category: Young, B M]]
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[[Category: Young, B.M]]
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[[Category: Sgc]]
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[[Category: Bharatham, N]]
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[[Category: Transcription]]
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[[Category: Bountra, C]]
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Revision as of 06:15, 28 February 2018

Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue

5n2m, resolution 1.54Å

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