6at5

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m (Protected "6at5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6at5 is ON HOLD until Paper Publication
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==Crystal structure of HLA-B*07:02 in complex with an NY-ESO-1 peptide==
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<StructureSection load='6at5' size='340' side='right' caption='[[6at5]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors: Gully, B.S., Rossjohn, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6at5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AT5 FirstGlance]. <br>
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Description: HLA-B7
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6at6|6at6]], [[6avf|6avf]], [[6avg|6avg]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6at5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6at5 OCA], [http://pdbe.org/6at5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6at5 RCSB], [http://www.ebi.ac.uk/pdbsum/6at5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6at5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1B07_HUMAN 1B07_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gully, B S]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn, J]]
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[[Category: Gully, B.S]]
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[[Category: Human leukocyte antigen]]
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[[Category: Immune system]]
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[[Category: Major histocompatibility complex]]

Revision as of 06:29, 28 February 2018

Crystal structure of HLA-B*07:02 in complex with an NY-ESO-1 peptide

6at5, resolution 1.50Å

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