6atw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox== | |
| - | + | <StructureSection load='6atw' size='340' side='right' caption='[[6atw]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6atw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atw OCA], [http://pdbe.org/6atw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atw RCSB], [http://www.ebi.ac.uk/pdbsum/6atw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atw ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[Category: Gewe, M | + | [[http://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU]] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gewe, M M]] | ||
[[Category: Rupert, P]] | [[Category: Rupert, P]] | ||
| + | [[Category: Strong, R K]] | ||
| + | [[Category: Cystine knot]] | ||
| + | [[Category: Knottin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 06:29, 28 February 2018
Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
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Categories: Gewe, M M | Rupert, P | Strong, R K | Cystine knot | Knottin | Toxin
