6ava
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox== | |
| - | + | <StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ava]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6atl|6atl]], [[6atm|6atm]], [[6atn|6atn]], [[6ats|6ats]], [[6atu|6atu]], [[6atw|6atw]], [[6aty|6aty]], [[6au7|6au7]], [[6aup|6aup]], [[6av8|6av8]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr> |
| - | [[Category: Gewe, M | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gewe, M M]] | ||
[[Category: Rupert, P]] | [[Category: Rupert, P]] | ||
| - | [[Category: Strong, R | + | [[Category: Strong, R K]] |
| + | [[Category: Cystine knot]] | ||
| + | [[Category: Knottin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 06:30, 28 February 2018
Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
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Categories: Gewe, M M | Rupert, P | Strong, R K | Cystine knot | Knottin | Toxin
