6ax3

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m (Protected "6ax3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ax3 is ON HOLD until Paper Publication
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==Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA)==
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<StructureSection load='6ax3' size='340' side='right' caption='[[6ax3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Lee, S., Liu, H., Wang, Y., Dai, S., Zhang, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ax3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AX3 FirstGlance]. <br>
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Description: Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene>, <scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
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[[Category: Wang, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ax3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ax3 OCA], [http://pdbe.org/6ax3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ax3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ax3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ax3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
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__TOC__
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</StructureSection>
[[Category: Dai, S]]
[[Category: Dai, S]]
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[[Category: Lee, S]]
[[Category: Liu, H]]
[[Category: Liu, H]]
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[[Category: Lee, S]]
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[[Category: Wang, Y]]
[[Category: Zhang, G]]
[[Category: Zhang, G]]
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[[Category: Demethylase]]
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[[Category: Endopeptidase]]
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[[Category: Exopeptidase]]
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[[Category: Histone]]
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[[Category: Hydrolase]]
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[[Category: Jumonji]]

Revision as of 06:30, 28 February 2018

Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA)

6ax3, resolution 2.25Å

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