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6bhv

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'''Unreleased structure'''
 
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The entry 6bhv is ON HOLD until Paper Publication
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==Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)==
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<StructureSection load='6bhv' size='340' side='right' caption='[[6bhv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Pascal, J.M., Langelier, M.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bhv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHV FirstGlance]. <br>
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Description: Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DQV:[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+[(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+dihydrogen+diphosphate+(non-preferred+name)'>DQV</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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[[Category: Pascal, J.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhv OCA], [http://pdbe.org/6bhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bhv RCSB], [http://www.ebi.ac.uk/pdbsum/6bhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhv ProSAT]</span></td></tr>
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[[Category: Langelier, M.F]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Langelier, M F]]
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[[Category: Pascal, J M]]
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[[Category: Adp-ribose]]
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[[Category: Artd1]]
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[[Category: Non-hydrolyzable nad+ analog]]
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[[Category: Parp]]
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[[Category: Parp-1]]
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[[Category: Transferase]]

Revision as of 06:32, 28 February 2018

Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)

6bhv, resolution 2.30Å

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