6fbv

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m (Protected "6fbv" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6fbv is ON HOLD
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==Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin==
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<StructureSection load='6fbv' size='340' side='right' caption='[[6fbv]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Das, K., Lin, W., Ebright, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fbv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBV FirstGlance]. <br>
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Description: Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FI8:Fidaxomicin'>FI8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbv OCA], [http://pdbe.org/6fbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbv RCSB], [http://www.ebi.ac.uk/pdbsum/6fbv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RPOZ_MYCTU RPOZ_MYCTU]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOA_MYCTU RPOA_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00059]<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOC_MYCTU RPOC_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322]<ref>PMID:22570422</ref> [[http://www.uniprot.org/uniprot/RPOB_MYCTU RPOB_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [[http://www.uniprot.org/uniprot/SIGA_MYCTU SIGA_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable).<ref>PMID:12354223</ref> <ref>PMID:20729364</ref> <ref>PMID:22570422</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Das, K]]
[[Category: Ebright, E]]
[[Category: Ebright, E]]
[[Category: Lin, W]]
[[Category: Lin, W]]
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[[Category: Das, K]]
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[[Category: Antibiotic]]
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[[Category: Ccdc 114782]]
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[[Category: Clostridium difficile]]
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[[Category: Drug]]
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[[Category: Inhibitor]]
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[[Category: Lipiarmycin]]
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[[Category: Rna pol]]
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[[Category: Rnap]]
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[[Category: Tiacumicin b]]
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[[Category: Transcription]]

Revision as of 06:38, 28 February 2018

Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin

6fbv, resolution 3.50Å

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