2vcj
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==4,5 | + | |
| + | ==4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer== | ||
<StructureSection load='2vcj' size='340' side='right' caption='[[2vcj]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2vcj' size='340' side='right' caption='[[2vcj]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EQ:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2EQ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EQ:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2EQ</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cdd|2cdd]], [[1uy9|1uy9]], [[1uy6|1uy6]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[1yc4|1yc4]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[2bt0|2bt0]], [[1uyg|1uyg]], [[1uye|1uye]], [[1uyl|1uyl]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[1yc1|1yc1]], [[2ccs|2ccs]], [[1uyc|1uyc]], [[1uy7|1uy7]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[1uyi|1uyi]], [[2byh|2byh]], [[1uyd|1uyd]], [[2byi|2byi]], [[2vci|2vci]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cdd|2cdd]], [[1uy9|1uy9]], [[1uy6|1uy6]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[1yc4|1yc4]], [[1uy8|1uy8]], [[2bug|2bug]], [[2uwd|2uwd]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[2bt0|2bt0]], [[1uyg|1uyg]], [[1uye|1uye]], [[1uyl|1uyl]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[1yc1|1yc1]], [[2ccs|2ccs]], [[1uyc|1uyc]], [[1uy7|1uy7]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[1uyi|1uyi]], [[2byh|2byh]], [[1uyd|1uyd]], [[2byi|2byi]], [[2vci|2vci]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcj OCA], [http://pdbe.org/2vcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcj RCSB], [http://www.ebi.ac.uk/pdbsum/2vcj PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcj OCA], [http://pdbe.org/2vcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcj RCSB], [http://www.ebi.ac.uk/pdbsum/2vcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 13: | Line 14: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcj_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcj_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 28: | Line 29: | ||
</div> | </div> | ||
<div class="pdbe-citations 2vcj" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2vcj" style="background-color:#fffaf0;"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 59: | Line 57: | ||
[[Category: Massey, A]] | [[Category: Massey, A]] | ||
[[Category: Matthews, T P]] | [[Category: Matthews, T P]] | ||
| - | [[Category: | + | [[Category: McDonald, E]] |
[[Category: Northfield, C J]] | [[Category: Northfield, C J]] | ||
[[Category: Pearl, L H]] | [[Category: Pearl, L H]] | ||
| Line 73: | Line 71: | ||
[[Category: Workman, P]] | [[Category: Workman, P]] | ||
[[Category: Wright, L]] | [[Category: Wright, L]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
| + | [[Category: Cytoplasm]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Stress response]] | [[Category: Stress response]] | ||
Revision as of 06:58, 28 February 2018
4,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
| |||||||||||
Categories: Human | Aherne, W | Barril, X | Borgognoni, J | Boxal, K | Brough, P A | Cansfield, J E | Cheung, K M | Collins, I | Davies, N G.M | Drysdale, M J | Dymock, B | Eccles, S A | Finch, H | Fink, A | Hayes, A | Howes, R | Hubbard, R E | James, K | Jordan, A M | Lockie, A | Martins, V | Massey, A | Matthews, T P | McDonald, E | Northfield, C J | Pearl, L H | Prodromou, C | Ray, S | Raynaud, F I | Roughley, S D | Sharp, S Y | Surgenor, A | Walmsley, D L | Webb, P | Wood, M | Workman, P | Wright, L | Alternative splicing | Atp-binding | Chaperone | Cytoplasm | Nucleotide-binding | Phosphorylation | Stress response
