5oak
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5oak' size='340' side='right' caption='[[5oak]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5oak' size='340' side='right' caption='[[5oak]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5oak]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OAK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5oak]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OAK FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">par-6, CG5884, Dmel_CG5884 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oak OCA], [http://pdbe.org/5oak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oak RCSB], [http://www.ebi.ac.uk/pdbsum/5oak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oak ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oak OCA], [http://pdbe.org/5oak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oak RCSB], [http://www.ebi.ac.uk/pdbsum/5oak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oak ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Polarity is a fundamental property of most cell types. The Par protein complex is a major driving force in generating asymmetrically localized protein networks and consists of atypical protein kinase C (aPKC), Par3, and Par6. Dysfunction of this complex causes developmental abnormalities and diseases such as cancer. We identified a PDZ domain-binding motif in Par6 that was essential for its interaction with Par3 in vitro and for Par3-mediated membrane localization of Par6 in cultured cells. In fly embryos, we observed that the PDZ domain-binding motif was functionally redundant with the PDZ domain in targeting Par6 to the cortex of epithelial cells. Our structural analyses by x-ray crystallography and NMR spectroscopy showed that both the PDZ1 and PDZ3 domains but not the PDZ2 domain in Par3 engaged in a canonical interaction with the PDZ domain-binding motif in Par6. Par3 thus has the potential to recruit two Par6 proteins simultaneously, which may facilitate the assembly of polarity protein networks through multivalent PDZ domain interactions. | ||
| + | |||
| + | Structural basis for the interaction between the cell polarity proteins Par3 and Par6.,Renschler FA, Bruekner SR, Salomon PL, Mukherjee A, Kullmann L, Schutz-Stoffregen MC, Henzler C, Pawson T, Krahn MP, Wiesner S Sci Signal. 2018 Feb 13;11(517). pii: 11/517/eaam9899. doi:, 10.1126/scisignal.aam9899. PMID:29440511<ref>PMID:29440511</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5oak" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Drome]] | ||
[[Category: Bruekner, S R]] | [[Category: Bruekner, S R]] | ||
[[Category: Wiesner, S]] | [[Category: Wiesner, S]] | ||
[[Category: Cell polarity protein]] | [[Category: Cell polarity protein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 07:08, 28 February 2018
Structure of the dmPar3 PDZ1 domain in complex with the dmPar6 PBM
| |||||||||||
