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Sandbox Reserved 1374

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<StructureSection load='1eg4' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1eg4' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
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==Structure==
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Dystrophin is a protein located between the sarcolemma and the outermost layer of myofilaments in the muscle fiber (myofiber). It is a cohesive protein, linking actin filaments to another support protein that resides on the inside surface of each muscle fiber’s plasma membrane (sarcolemma). This support protein on the inside surface of the sarcolemma in turn links to two other consecutive proteins for a total of three linking proteins. The final linking protein is attached to the fibrous endomysium of the entire muscle fiber. Dystrophin supports muscle fiber strength, and the absence of dystrophin reduces muscle stiffness, increases sarcolemmal deformability, and compromises the mechanical stability of costameres and their connections to nearby myofibrils; as shown in recent studies where biomechanical properties of the sarcolemma and its links through costameres to the contractile apparatus were measured, and helps to prevent muscle fiber injury. Movement of thin filaments (actin) creates a pulling force on the extracellular connective tissue that eventually becomes the tendon of the muscle.
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The Dystrophin-Glycoprotein Complex (DGC) is made up of two major components. The larger of the two components is the dystrophin protein. Several substituents of the protein are then glycosylated. This glycosylation is what turns dystrophin into a Dystrophin-Glycoprotein Complex.
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The DGC has a Beta-Dystroglycan 15 polypeptide sequence on it depicted <scene name='77/777694/Beta-dystroglycan/1'>here</scene>.
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== Function ==
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The DGC Complex has a Beta-Dystroglycan 15 polypeptide sequence on it depicted <scene name='77/777694/Beta-dystroglycan/1'>here</scene>.
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Dystrophin is a protein found in the muscle cell. It works to link actin filaments to another protein in the sarcolemma of the muscle's plasma membrane. The protein inside the sarcolemma connects the dystrophin to even more connective proteins to make three total linking proteins. This combination of proteins--with dystrophin playing the most important role-- supports the strength, stability, and overall function of the muscle. If dystrophin is not present, the muscle will become stiff and possibly deformed or at least at an increased risk of injury.
== Diseases ==
== Diseases ==

Revision as of 02:22, 1 March 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Dystrophin-Glycoprotein Complex

Caption for this structure

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References

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