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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

Epithelial-cadherin (1-213), or E-cadherin is a calcium-dependent cell adhesion protein. E-cadherin regulates cell-to-cell interactions, adhesion of bacteria to mammalian cells, and cell mobility. E-cadherin also plays a crucial role in the normal blastula formation in several animal cells.

Relevance

E-cadherin is a tumor suppressor gene. Degradation or loss of function of the gene is associated with increased proliferation and metastasis of tumors. Since E-cadherin is related to the adhesion strength within epithelial tissue, a decrease in the ability or quantity of E-cadherin allows for increased cell mobility. This may allow cancerous cells to proliferate more rapidly and invade nearby tissues at a higher rate. Mutations in the E-cadherin protein are linked to a series of cancers, including gastric, thyroid, colorectal, breast, and ovarian cancers.

Structural highlights

E-cadherin 1 is 213 amino acids long. E-cadherin is composed of five cadherin extensions, a transmembrane region, and a cytoplasmic tail. E-cadherin cell-to-cell junctions are often located close to actin-filaments within the cytoskeleton of a cell.

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

https://www.ebi.ac.uk/pdbe/entry/pdb/2o72/biology http://www.uniprot.org/uniprot/P12830 https://en.wikipedia.org/wiki/CDH1_(gene)