Sandbox Reserved 1391
From Proteopedia
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== Overview == | == Overview == | ||
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<Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <Structure load='4GX8' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /></StructureSection>{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970. | DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. | + | This enzyme contains many different regions that all have different properties. These are the <scene name='77/777711/Hydrophobic_and_polar_regions/1'>hydrophobic and polar regions</scene> of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. This next scene shows the <scene name='77/777711/Secondary_structure/2'>secondary structure </scene> of the polymerase. This consists of alpha helices which are pink and beta pleated sheets which are yellow. These secondary structures form via hydrogen bonding between the amino acid backbones. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:45, 1 March 2018
Contents |
Overview
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| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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More help: Help:Editing |
DNA polymerase 3 is the primary enzyme responsible for prokaryotic DNA replication. It was first discovered by Thomas Kornberg and Malcolm Gefter in 1970.
Function
As mentioned DNA Polymerase 3 is responsible for replicating DNA in prokaryotes. The two most important subunits of this polymerase are the α subunit that links the nucleotides together via a phosphodiester bond and the ε subunit that ensures the bases are accurate via proofreading mechanisms. It can synthesize base pairs at a rate of about 1000 nucleotides per second and can only move in the 5' to 3' direction.
Relevance
Structural highlights
This enzyme contains many different regions that all have different properties. These are the of the polymerase. The purple regions are towards the outside because they are polar and therefore hydrophilic. The gray regions are hydrophobic regions. This next scene shows the of the polymerase. This consists of alpha helices which are pink and beta pleated sheets which are yellow. These secondary structures form via hydrogen bonding between the amino acid backbones. </StructureSection>
