2fau
From Proteopedia
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|PDB= 2fau |SIZE=350|CAPTION= <scene name='initialview01'>2fau</scene>, resolution 2.10Å | |PDB= 2fau |SIZE=350|CAPTION= <scene name='initialview01'>2fau</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | + | |LIGAND= <scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= VPS26A, VPS26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= VPS26A, VPS26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fau OCA], [http://www.ebi.ac.uk/pdbsum/2fau PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fau RCSB]</span> | ||
}} | }} | ||
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[[Category: Rojas, R.]] | [[Category: Rojas, R.]] | ||
[[Category: Shi, H.]] | [[Category: Shi, H.]] | ||
| - | [[Category: GOL]] | ||
[[Category: arrestin]] | [[Category: arrestin]] | ||
[[Category: retromer]] | [[Category: retromer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:00:11 2008'' |
Revision as of 00:00, 31 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | VPS26A, VPS26 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human vps26
Overview
The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.
About this Structure
2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284
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