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5n6p
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==AMPA receptor NTD mutant== | |
| - | + | <StructureSection load='5n6p' size='340' side='right' caption='[[5n6p]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5n6p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6p OCA], [http://pdbe.org/5n6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6p RCSB], [http://www.ebi.ac.uk/pdbsum/5n6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6p ProSAT]</span></td></tr> |
| - | [[Category: Krieger, J | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Krieger, J M]] | ||
[[Category: Rossmann, M]] | [[Category: Rossmann, M]] | ||
| + | [[Category: Ampa]] | ||
| + | [[Category: Glutamate receptor]] | ||
| + | [[Category: Ntd]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 04:58, 8 March 2018
AMPA receptor NTD mutant
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