5v03
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA== | |
| - | + | <StructureSection load='5v03' size='340' side='right' caption='[[5v03]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5v03]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V03 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=658:N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine'>658</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v02|5v02]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v03 OCA], [http://pdbe.org/5v03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v03 RCSB], [http://www.ebi.ac.uk/pdbsum/5v03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v03 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCNN2_HUMAN KCNN2_HUMAN]] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Liu, S]] | [[Category: Liu, S]] | ||
| + | [[Category: Activator]] | ||
| + | [[Category: Calcium-activated ion channel]] | ||
| + | [[Category: Calmodulin]] | ||
| + | [[Category: Transport protein-metal binding protein complex]] | ||
Revision as of 05:01, 8 March 2018
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
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