5w43

From Proteopedia

(Difference between revisions)

Revision as of 05:02, 8 March 2018

Structure of the two-component response regulator RcsB-DNA complex

Structural highlights

5w43 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RCSB_ECOLI] Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of the cryptic bgl operon. The RcsB-BglJ activity is probably independent of RcsB phosphorylation.[HAMAP-Rule:MF_00981]^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Wehland M, Bernhard F. The RcsAB box. Characterization of a new operator essential for the regulation of exopolysaccharide biosynthesis in enteric bacteria. J Biol Chem. 2000 Mar 10;275(10):7013-20. PMID:10702265
↑ Takeda S, Fujisawa Y, Matsubara M, Aiba H, Mizuno T. A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC --> YojN --> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol Microbiol. 2001 Apr;40(2):440-50. PMID:11309126
↑ Davalos-Garcia M, Conter A, Toesca I, Gutierrez C, Cam K. Regulation of osmC gene expression by the two-component system rcsB-rcsC in Escherichia coli. J Bacteriol. 2001 Oct;183(20):5870-6. PMID:11566985 doi:http://dx.doi.org/10.1128/JB.***********-5876.2001
↑ Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. J Bacteriol. 2003 Oct;185(19):5735-46. PMID:13129944
↑ Gervais FG, Phoenix P, Drapeau GR. The rcsB gene, a positive regulator of colanic acid biosynthesis in Escherichia coli, is also an activator of ftsZ expression. J Bacteriol. 1992 Jun;174(12):3964-71. PMID:1597415
↑ Castanie-Cornet MP, Cam K, Bastiat B, Cros A, Bordes P, Gutierrez C. Acid stress response in Escherichia coli: mechanism of regulation of gadA transcription by RcsB and GadE. Nucleic Acids Res. 2010 Jun;38(11):3546-54. doi: 10.1093/nar/gkq097. Epub 2010, Feb 26. PMID:20189963 doi:http://dx.doi.org/10.1093/nar/gkq097
↑ Venkatesh GR, Kembou Koungni FC, Paukner A, Stratmann T, Blissenbach B, Schnetz K. BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS. J Bacteriol. 2010 Dec;192(24):6456-64. doi: 10.1128/JB.00807-10. Epub 2010 Oct, 15. PMID:20952573 doi:http://dx.doi.org/10.1128/JB.00807-10

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5w43"

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5w43 is ON HOLD  until Paper Publication
+==Structure of the two-component response regulator RcsB-DNA complex==
+<StructureSection load='5w43' size='340' side='right' caption='[[5w43]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5w43]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W43 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w43 OCA], [http://pdbe.org/5w43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w43 RCSB], [http://www.ebi.ac.uk/pdbsum/5w43 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w43 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RCSB_ECOLI RCSB_ECOLI]] Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of the cryptic bgl operon. The RcsB-BglJ activity is probably independent of RcsB phosphorylation.[HAMAP-Rule:MF_00981]<ref>PMID:10702265</ref> <ref>PMID:11309126</ref> <ref>PMID:11566985</ref> <ref>PMID:13129944</ref> <ref>PMID:1597415</ref> <ref>PMID:20189963</ref> <ref>PMID:20952573</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Anderson, W F]]
+[[Category: Structural genomic]]
+[[Category: Filippova, E V]]
+[[Category: Pshenychnyi, S]]
+[[Category: Warwzak, Z]]
+[[Category: Csgid]]
+[[Category: Dna binding protein]]
+[[Category: Fixj/narl]]
+[[Category: Rcs phosphorelay]]
+[[Category: Response regulator]]
+[[Category: Two-component signal transduction]]

5w43

From Proteopedia

Revision as of 05:02, 8 March 2018

Structure of the two-component response regulator RcsB-DNA complex

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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