5wjq

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m (Protected "5wjq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5wjq is ON HOLD until Paper Publication
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==mouseZFP568-ZnF2-11 in complex with DNA==
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<StructureSection load='5wjq' size='340' side='right' caption='[[5wjq]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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Authors: Patel, A., Cheng, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wjq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WJQ FirstGlance]. <br>
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Description: mouseZFP568-ZnF2-11 in complex with DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wjq OCA], [http://pdbe.org/5wjq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wjq RCSB], [http://www.ebi.ac.uk/pdbsum/5wjq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wjq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cheng, X]]
[[Category: Cheng, X]]
[[Category: Patel, A]]
[[Category: Patel, A]]
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[[Category: C2h2 type zinc finger]]
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[[Category: Dna binding]]
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[[Category: Gene regulation]]
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[[Category: Gene regulation-dna complex]]
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[[Category: Transferase-dna complex]]

Revision as of 05:02, 8 March 2018

mouseZFP568-ZnF2-11 in complex with DNA

5wjq, resolution 2.79Å

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