6c6y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain== | |
| - | + | <StructureSection load='6c6y' size='340' side='right' caption='[[6c6y]], [[Resolution|resolution]] 3.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c6y]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6y OCA], [http://pdbe.org/6c6y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6y RCSB], [http://www.ebi.ac.uk/pdbsum/6c6y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6y ProSAT]</span></td></tr> |
| - | [[Category: Graham, B | + | </table> |
| - | [[Category: Joyce, M | + | == Function == |
| - | [[Category: Kwong, P | + | [[http://www.uniprot.org/uniprot/SPIKE_CVEMC SPIKE_CVEMC]] S1 attaches the virion to the cell membrane by interacting with host DPP4, initiating the infection.<ref>PMID:23486063</ref> S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes (By similarity). |
| - | [[Category: Mascola, J | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Graham, B S]] | ||
| + | [[Category: Joyce, M G]] | ||
| + | [[Category: Kwong, P D]] | ||
| + | [[Category: Mascola, J R]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Neutralizing]] | ||
| + | [[Category: Vaccine]] | ||
Revision as of 05:08, 8 March 2018
Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain
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