4q6u
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6u OCA], [http://pdbe.org/4q6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6u RCSB], [http://www.ebi.ac.uk/pdbsum/4q6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6u OCA], [http://pdbe.org/4q6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6u RCSB], [http://www.ebi.ac.uk/pdbsum/4q6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The genome of the human pathogen Mycobacterium tuberculosis (Mtb) encodes approximately 4,400 proteins, but one third of them have unknown functions. We solved the crystal structure of Rv3651, a hypothetical protein with no discernible similarity to proteins with known function. Rv3651 has a three-domain architecture that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are sensor domains that are typically linked to signaling effector molecules. Unlike these sensor-effector proteins, Rv3651 is an unusual sensor domain-only protein with highly divergent sequence. The structure suggests that Rv3651 integrates multiple different signals and serves as a scaffold to facilitate signal transfer. | ||
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| + | Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.,Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5. PMID:29119630<ref>PMID:29119630</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4q6u" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 05:54, 8 March 2018
Crystal structure of a putative uncharacterized protein from Mycobacterium tuberculosis
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