Alice Clark/ATPsynthase

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- right mouse button for more options and information (control-click on a Mac).
- right mouse button for more options and information (control-click on a Mac).
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'''Have a go yourself now ==>'''
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'''Have a go yourself now ==>'''
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'''Exploring the ATP synthase molecule'''
'''Exploring the ATP synthase molecule'''
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ATP synthase is built up of different groups of proteins: the F0, the F1, the stator and the axel - each group with a important role.
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ATP synthase is built up of different groups of proteins: the F0, the F1, the stator and the axel - each group has an important role.
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The <scene name='78/781973/Alpha-beta/1'>F1 motor</scene> contains alpha (shown in light blue) and beta (shown in dark blue) protein chains. It also binds the adenosine diphosphate (ADP) molecules and the adenosine triphosphate (ATP) <scene name='78/781973/Atpandadp/1'>binding sites</scene>. See if you can zoom in on the ATP identify how many phosphates (atoms shown in orange) are found.
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The <scene name='78/781973/Alpha-beta/1'>F1 motor</scene> contains alpha (shown in light blue) and beta (shown in dark blue) protein chains.
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'''Q1: How many chains makeup the F1 region, and what is it's role in generating ATP?'''
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'''Q1: How many protein chains comprise the F1 region?'''
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The F1 binds the adenosine diphosphate (ADP) molecules and the adenosine triphosphate (ATP) <scene name='78/781973/Atpandadp/1'>binding sites</scene>. See if you can zoom in on the ATP identify the phosphate atoms (orange).
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The <scene name='78/781973/Axel/1'>axle</scene> rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released.
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The <scene name='78/781973/Axel/1'>axle</scene> rotates putting the motor into three different conformations as the ADP binds, the phosphate bond is formed and the ATP being released.
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'''Q5: What is the role of the axel?'''
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<scene name='78/781973/F0/1'>The F0</scene> is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of <scene name='78/781973/Aspgluchain/1'>aspartic acid residues</scene> or glutamic acid (amino acids) in the F0 motor, and then transferred to an <scene name='78/781973/Arg/1'>arginine</scene> (ARG) amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane.
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<scene name='78/781973/F0/1'>The F0</scene> is a circular rotor that is formed of alpha helices that sit in the mitochondrial membrane. The hydrogen ions travel around the circular F0 motor, and turning the rotor in the process, much like a water wheel. The hydrogens are passed alone a chain of <scene name='78/781973/Aspgluchain/1'>'''aspartic acid residues'''</scene> or glutamic acid (amino acids) in the F0 motor, and then transferred to an <scene name='78/781973/Arg/1'>arginine</scene> (ARG) amino acid. The arginine passes the hydrogen to the rotor, which turns all the way around. Then the hydrogen is then passed to the opposite side of the membrane.
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'''Q4: What are the two key amino acid that bind the hydrogen's in the ATP generation?'''
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'''Q4: Name two key amino acids, one acidic and one basic, that bind the hydrogen's in the ATP generation?'''
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Revision as of 17:06, 10 March 2018

ATP Synthase

ATP Synthase (PDB entry 5lqz)

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Proteopedia Page Contributors and Editors (what is this?)

Alice Clark

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