Aldose Reductase

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	**[[2bgq]] – bAldR - barley<br />		**[[2bgq]] – bAldR - barley<br />
	**[[2bgs]] - bAldR+NADP<br />		**[[2bgs]] - bAldR+NADP<br />
-	**[[5jh1]] – maAldR – maize<br />	+	**[[4gca]] – AldR – mouse<br />
		+	**[[5jh1]], [[5jgy]] – maAldR – maize<br />
		+	**[[5jgw]] – maAldR + NADP<br />
	*Aldose Reductase+inhibitors		*Aldose Reductase+inhibitors

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Revision as of 11:08, 11 March 2018

spinqualitylabelsall models Human aldose reductase complex with cofactor NADP (PDB code 1ads) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.[1] Disease The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. Structural highlights AldR structure is of a . The .[2]

3D Structures of Aldose Reductase

Updated on 11-March-2018

References

1. ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
2. ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098