2flr
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=7NH:[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA'>7NH</scene> | |LIGAND= <scene name='pdbligand=7NH:[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA'>7NH</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span> |
|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2flb|2FLB]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flr OCA], [http://www.ebi.ac.uk/pdbsum/2flr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2flr RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Young, W B.]] | [[Category: Young, W B.]] | ||
[[Category: Yu, C.]] | [[Category: Yu, C.]] | ||
| - | [[Category: 7NH]] | ||
[[Category: 5-azaindole inhibitor]] | [[Category: 5-azaindole inhibitor]] | ||
[[Category: s1 site]] | [[Category: s1 site]] | ||
[[Category: short hydrogen bond]] | [[Category: short hydrogen bond]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:30 2008'' |
Revision as of 00:04, 31 March 2008
| |||||||
| , resolution 2.35Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | F7 (Homo sapiens), F3 (Homo sapiens) | ||||||
| Activity: | Coagulation factor VIIa, with EC number 3.4.21.21 | ||||||
| Related: | 2FLB
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Novel 5-Azaindole Factor VIIa Inhibitors
Contents |
Overview
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
Disease
Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
2FLR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Novel 5-azaindole factor VIIa inhibitors., Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18. PMID:16621549
Page seeded by OCA on Mon Mar 31 03:04:30 2008
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Green, M J. | Hu, H. | Katz, B A. | Kolesnikov, A. | Leahy, E M. | Riggs, J R. | Shrader, W D. | Sprengeler, P A. | Tong, Z. | Vijaykumar, D. | Wahl, T A. | Wesson, K E. | Young, W B. | Yu, C. | 5-azaindole inhibitor | S1 site | Short hydrogen bond
