5lbo

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'''Unreleased structure'''
 
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The entry 5lbo is ON HOLD until Paper Publication
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==Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001==
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<StructureSection load='5lbo' size='340' side='right' caption='[[5lbo]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Singh, A.K., Brown, D.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lbo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LBO FirstGlance]. <br>
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Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6M5:(4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one'>6M5</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g2b|5g2b]], [[5g57|5g57]], [[5g5v|5g5v]], [[5l8c|5l8c]], [[5l8y|5l8y]], [[5l9h|5l9h]], [[5laq|5laq]]</td></tr>
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[[Category: Brown, D.G]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
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[[Category: Singh, A.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbo OCA], [http://pdbe.org/5lbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lbo RCSB], [http://www.ebi.ac.uk/pdbsum/5lbo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
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[[Category: Brown, D G]]
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[[Category: Singh, A K]]
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[[Category: Alternative splicing]]
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[[Category: Camp hydrolysis]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase]]

Revision as of 06:17, 14 March 2018

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001

5lbo, resolution 2.25Å

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