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5uqr
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus== | |
| - | + | <StructureSection load='5uqr' size='340' side='right' caption='[[5uqr]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5uqr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UQR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8JD:[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+(3R)-4-[(3-{[2-(ethylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl+dihydrogen+diphosphate+(non-preferred+name)'>8JD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uqo|5uqo]], [[5uqq|5uqq]], [[5uqs|5uqs]], [[5uqu|5uqu]]</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqr OCA], [http://pdbe.org/5uqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uqr RCSB], [http://www.ebi.ac.uk/pdbsum/5uqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRPC_ASPFM PRPC_ASPFM]] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.<ref>PMID:16008561</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chruszcz, M]] | [[Category: Chruszcz, M]] | ||
[[Category: Schlachter, C]] | [[Category: Schlachter, C]] | ||
| + | [[Category: 2-methylcitrate synthase]] | ||
| + | [[Category: Citrate synthase]] | ||
| + | [[Category: Ethyl-coa]] | ||
| + | [[Category: Mcsa]] | ||
| + | [[Category: Oxaloacetate]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:22, 14 March 2018
Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus
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