5wna
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of antibody 3D3 bound to the central conserved region of RSV G== | |
| - | + | <StructureSection load='5wna' size='340' side='right' caption='[[5wna]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wna]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wna OCA], [http://pdbe.org/5wna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wna RCSB], [http://www.ebi.ac.uk/pdbsum/5wna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wna ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DuBois, R M]] | ||
| + | [[Category: Fedechkin, S O]] | ||
| + | [[Category: George, N L]] | ||
| + | [[Category: Kauvar, L M]] | ||
| + | [[Category: Wolff, J T]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: G glycoprotein]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Rsv]] | ||
| + | [[Category: Viral attachment protein]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 06:25, 14 March 2018
Structure of antibody 3D3 bound to the central conserved region of RSV G
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