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6cby
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975== | |
| - | + | <StructureSection load='6cby' size='340' side='right' caption='[[6cby]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cby]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CBY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EW4:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone'>EW4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cby OCA], [http://pdbe.org/6cby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cby RCSB], [http://www.ebi.ac.uk/pdbsum/6cby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cby ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: BROWN, P J]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Casimiro-Garcia, A]] | ||
| + | [[Category: DONG, A]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Hutchinson, A]] | [[Category: Hutchinson, A]] | ||
| - | [[Category: | + | [[Category: KUMPF, R]] |
| + | [[Category: OWEN, A]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Seitova, A]] | [[Category: Seitova, A]] | ||
| - | [[Category: | + | [[Category: TATLOCK, J]] |
| - | + | [[Category: TAYLOR, A]] | |
| - | [[Category: | + | [[Category: WU, H]] |
| - | [[Category: | + | [[Category: ZENG, H]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Smyd2 mtf9975 inhibitor]] |
| - | + | [[Category: Transferase-inhibitor complex]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | [[Category: | + | |
| - | [[Category: | + | |
Revision as of 06:31, 14 March 2018
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975
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