5wop
From Proteopedia
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<StructureSection load='5wop' size='340' side='right' caption='[[5wop]], [[Resolution|resolution]] 1.52Å' scene=''> | <StructureSection load='5wop' size='340' side='right' caption='[[5wop]], [[Resolution|resolution]] 1.52Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wop]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WOP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WOP FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[4enf|4enf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[4enf|4enf]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 9INFA])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wop OCA], [http://pdbe.org/5wop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wop RCSB], [http://www.ebi.ac.uk/pdbsum/5wop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wop ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wop OCA], [http://pdbe.org/5wop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wop RCSB], [http://www.ebi.ac.uk/pdbsum/5wop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wop ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| - | + | In the face of increasing drug resistance and the rapidly increasing necessity for practicality in clinical settings, drugs targeting different viral proteins are needed in order to control influenza A and B. A small molecule that tenaciously adheres to the PB2cap binding domain, part of the heterotrimeric RNA polymerase machinery of influenza A virus and influenza B virus, is a promising drug candidate. Understanding the anatomic behavior of PB2cap upon ligand binding will aid in the development of a more robust inhibitor. In this report, the anatomic behavior of the influenza A virus PB2cap domain is established by solving the crystal structure of native influenza A virus PB2cap at 1.52 A resolution. By comparing it with the ligand-bound structure, the dissociation and rotation of the ligand-binding domain in PB2cap from the C-terminal domain is identified. This domain movement is present in many PB2cap structures, suggesting its functional relevance for polymerase activity. | |
| - | + | High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.,Constantinides A, Gumpper R, Severin C, Luo M Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):122-127. doi:, 10.1107/S2053230X18000894. Epub 2018 Feb 26. PMID:29497014<ref>PMID:29497014</ref> | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
Revision as of 06:57, 14 March 2018
High Resolution Structure of Mutant CA09-PB2cap
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