Cell death protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> | <StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> | ||
| - | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref> | + | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. |
</StructureSection> | </StructureSection> | ||
==3D structures of cell death protein== | ==3D structures of cell death protein== | ||
| Line 57: | Line 57: | ||
**[[5gqq]] - hCED-6 + heme-binding protein<br /> | **[[5gqq]] - hCED-6 + heme-binding protein<br /> | ||
| - | *CED-8 | + | *CED-8 (apoptosis-inducing factor 1) |
| - | **[[1gv4]] - mCED-8<br /> | + | **[[1gv4]], [[3gd3]] - mCED-8<br /> |
| - | **[[1m6i]] - hCED-8<br /> | + | **[[3gd4]] – mCED-8 + NAD <br /> |
| + | **[[5miu]] – mCED-8 (mutant) + FAD <br /> | ||
| + | **[[5miv]] – mCED-8 (mutant) + FAD + NAD<br /> | ||
| + | **[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br /> | ||
| + | **[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant) <br /> | ||
| + | **[[5fs9]] – hCED-8 (mutant) + FAD<br /> | ||
| + | **[[4bur]] – hCED-8 + NAD <br /> | ||
*CED-9 | *CED-9 | ||
Revision as of 09:55, 15 March 2018
| |||||||||||
3D structures of cell death protein
Updated on 15-March-2018
References
- ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
- ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
