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User:Kyle Burton/Sandbox1
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== Background & Significance == | == Background & Significance == | ||
| - | '''Sex Lethal Protein''' (i.e. Sxl) is a splicing repressor in the male developmental pathway of the common fruit fly, ''[https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''. Sxl regulates [https://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (tra) and the male-sex lethal | + | '''Sex Lethal Protein''' (i.e. Sxl) is a splicing repressor in the male developmental pathway of the common fruit fly, ''[https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''. Sxl regulates [https://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (tra) and the male-sex lethal (Msl-2) proteins. Tra is a splicing activator in the female developmental pathway. Msl2 modulates X chromosome application in male fruit flies. The mechanism for how Sxl targets these pathways differs slightly. In both scenarios, Sxl occupies the 3' splice site and prevents U2AF from binding. U2AF is a vital splicing factor observed in the male developmental pathway. In Msl-2 targeting, Sxl also |
Revision as of 16:08, 20 March 2018
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
