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User:Kyle Burton/Sandbox1
From Proteopedia
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== Background & Significance == | == Background & Significance == | ||
| - | '''Sex Lethal Protein''' (i.e. Sxl) is a splicing repressor in the male developmental pathway of the common fruit fly, ''[https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''. Sxl regulates [https://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (tra) and the male-sex lethal (Msl-2) proteins. Tra is a splicing activator in the female developmental pathway. Msl2 modulates X chromosome application in male fruit flies. The mechanism for how Sxl targets these pathways differs slightly. In both scenarios, Sxl occupies the 3' splice site and prevents U2AF from binding. U2AF is a vital splicing factor observed in the male developmental pathway. In Msl-2 targeting, Sxl also | + | '''Sex Lethal Protein''' (i.e. Sxl) is a splicing repressor in the male developmental pathway of the common fruit fly, ''[https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]''. Sxl regulates [https://en.wikipedia.org/wiki/Alternative_splicing alternative splicing] pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (tra) and the male-sex lethal (Msl-2) proteins. Tra is a splicing activator in the female developmental pathway. Msl2 modulates X chromosome application in male fruit flies. The mechanism for how Sxl targets these pathways differs slightly. In both scenarios, Sxl occupies the 3' splice site and prevents U2AF from binding. U2AF is a vital splicing factor observed in the male developmental pathway. In Msl-2 targeting, Sxl also blocks another regulatory splicing factor, TIA-1, and the [https://en.wikipedia.org/wiki/SnRNP U1 snRNP]. Sxl also has the ability to control its own splicing pattern in order to conserve female expression. It does so by surrounding [https://en.wikipedia.org/wiki/Exon Exon] 3 of its own RNA and creating a RNP complex to eliminate this exon. Upon this elimination, Sxl becomes active and female expression is maintained. The structural interactions with regards to the targeting of the 5' splice site and of its own mRNA transcript is much less understood than the competition of Sxl with U2AF at the 3' splice site. |
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Revision as of 16:35, 20 March 2018
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
