2ftb
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2ftb |SIZE=350|CAPTION= <scene name='initialview01'>2ftb</scene>, resolution 2.00Å | |PDB= 2ftb |SIZE=350|CAPTION= <scene name='initialview01'>2ftb</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=OLA:OLEIC ACID'>OLA</scene> | + | |LIGAND= <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2ft9|2FT9]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftb OCA], [http://www.ebi.ac.uk/pdbsum/2ftb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ftb RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Pietro, S M.Di.]] | [[Category: Pietro, S M.Di.]] | ||
[[Category: Santome, J A.]] | [[Category: Santome, J A.]] | ||
| - | [[Category: OLA]] | ||
[[Category: axolotl]] | [[Category: axolotl]] | ||
[[Category: babp]] | [[Category: babp]] | ||
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[[Category: oleic acid]] | [[Category: oleic acid]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:07:25 2008'' |
Revision as of 00:07, 31 March 2008
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| , resolution 2.00Å | |||||||
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| Ligands: | |||||||
| Related: | 2FT9
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to oleic acid
Overview
The family of the liver bile acid-binding proteins (L-BABPs), formerly called liver basic fatty acid-binding proteins (Lb-FABPs) shares fold and sequence similarity with the paralogous liver fatty acid-binding proteins (L-FABPs) but has a different stoichiometry and specificity of ligand binding. This article describes the first X-ray structure of a member of the L-BABP family, axolotl (Ambystoma mexicanum) L-BABP, bound to two different ligands: cholic and oleic acid. The protein binds one molecule of oleic acid in a position that is significantly different from that of either of the two molecules that bind to rat liver FABP. The stoichiometry of binding of cholate is of two ligands per protein molecule, as observed in chicken L-BABP. The cholate molecule that binds buried most deeply into the internal cavity overlaps well with the analogous bound to chicken L-BABP, whereas the second molecule, which interacts with the first only through hydrophobic contacts, is more external and exposed to the solvent.
About this Structure
2FTB is a Single protein structure of sequence from Ambystoma mexicanum. Full crystallographic information is available from OCA.
Reference
Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to cholic and oleic acid., Capaldi S, Guariento M, Perduca M, Di Pietro SM, Santome JA, Monaco HL, Proteins. 2006 Jul 1;64(1):79-88. PMID:16555310
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