5nao
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of TLR4 transmembrane domain (624-657) in DPC micelles== | |
| - | + | <StructureSection load='5nao' size='340' side='right' caption='[[5nao]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nao]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NAO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nao OCA], [http://pdbe.org/5nao PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nao RCSB], [http://www.ebi.ac.uk/pdbsum/5nao PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nao ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[Category: Arseniev, A | + | [[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:[http://omim.org/entry/611488 611488]]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. |
| - | [[Category: Goncharuk, M | + | == Function == |
| - | [[Category: Goncharuk, S | + | [[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.<ref>PMID:20711192</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arseniev, A S]] | ||
| + | [[Category: Goncharuk, M V]] | ||
| + | [[Category: Goncharuk, S A]] | ||
| + | [[Category: Mineev, K S]] | ||
| + | [[Category: Protein]] | ||
| + | [[Category: Protein receptor]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Toll-like receptor]] | ||
| + | [[Category: Transmembrane domain]] | ||
Revision as of 07:29, 21 March 2018
NMR structure of TLR4 transmembrane domain (624-657) in DPC micelles
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