5v9i

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'''Unreleased structure'''
 
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The entry 5v9i is ON HOLD until Paper Publication
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==Crystal structure of catalytic domain of G9a with MS0105==
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<StructureSection load='5v9i' size='340' side='right' caption='[[5v9i]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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Authors: Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Wu, H., Brown, P.J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5v9i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V9I FirstGlance]. <br>
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Description: Crystal structure of catalytic domain of G9a with MS0105
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=90P:N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine'>90P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v9j|5v9j]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v9i OCA], [http://pdbe.org/5v9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v9i RCSB], [http://www.ebi.ac.uk/pdbsum/5v9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v9i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN]] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Babault, N]]
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[[Category: Bountra, C]]
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[[Category: Brown, P J]]
[[Category: Dong, A]]
[[Category: Dong, A]]
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[[Category: Zeng, H]]
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[[Category: Edwards, A M]]
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[[Category: Babault, N]]
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[[Category: Jin, J]]
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[[Category: Walker, J.R]]
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[[Category: Liu, J]]
[[Category: Liu, J]]
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[[Category: Structural genomic]]
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[[Category: Walker, J R]]
[[Category: Wu, H]]
[[Category: Wu, H]]
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[[Category: Jin, J]]
 
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[[Category: Bountra, C]]
 
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[[Category: Arrowsmith, C.H]]
 
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[[Category: Brown, P.J]]
 
[[Category: Xiong, Y]]
[[Category: Xiong, Y]]
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[[Category: Edwards, A.M]]
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[[Category: Zeng, H]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Bat8]]
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[[Category: Ehmt2]]
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[[Category: Methyltransferase]]
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[[Category: Sgc]]
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[[Category: Transferase]]

Revision as of 07:32, 21 March 2018

Crystal structure of catalytic domain of G9a with MS0105

5v9i, resolution 1.74Å

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