6ckn

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m (Protected "6ckn" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ckn is ON HOLD
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==Crystal structure of an AF10 fragment==
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<StructureSection load='6ckn' size='340' side='right' caption='[[6ckn]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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Authors: Qin, S., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ckn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKN FirstGlance]. <br>
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Description: Crystal structure of an AF10 fragment
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckn OCA], [http://pdbe.org/6ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ckn RCSB], [http://www.ebi.ac.uk/pdbsum/6ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckn ProSAT]</span></td></tr>
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[[Category: Qin, S]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
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== Function ==
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[[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
[[Category: Li, Y]]
[[Category: Li, Y]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Edwards, A.M]]
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[[Category: Qin, S]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Structural genomic]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Dna binding protein]]
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[[Category: Sgc]]

Revision as of 07:42, 21 March 2018

Crystal structure of an AF10 fragment

6ckn, resolution 2.49Å

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