2g0d
From Proteopedia
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|PDB= 2g0d |SIZE=350|CAPTION= <scene name='initialview01'>2g0d</scene>, resolution 2.21Å | |PDB= 2g0d |SIZE=350|CAPTION= <scene name='initialview01'>2g0d</scene>, resolution 2.21Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= nisC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1360 Lactococcus lactis subsp. lactis]) | |GENE= nisC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1360 Lactococcus lactis subsp. lactis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2go2|2GO2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0d OCA], [http://www.ebi.ac.uk/pdbsum/2g0d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g0d RCSB]</span> | ||
}} | }} | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Nair, S K.]] | [[Category: Nair, S K.]] | ||
| - | [[Category: ZN]] | ||
[[Category: alpha barrel]] | [[Category: alpha barrel]] | ||
[[Category: alpha toroid]] | [[Category: alpha toroid]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:10:07 2008'' |
Revision as of 00:10, 31 March 2008
| |||||||
| , resolution 2.21Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | nisC (Lactococcus lactis subsp. lactis) | ||||||
| Related: | 2GO2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Nisin cyclase
Overview
Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
About this Structure
2G0D is a Single protein structure of sequence from Lactococcus lactis subsp. lactis. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981
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