Antibody 3D structures
From Proteopedia
(Difference between revisions)
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'''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | '''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | ||
'''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti-HIV Fab.<br /> | '''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti-HIV Fab.<br /> | ||
| - | '''Lama antibodies''' or '''nanobodies''' are natural single-domain antibodies containing just the heavy chain. | + | '''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain. '''scFv''' is a single chain variable fragment is a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. |
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Fab | *Fab | ||
| - | **[[7fab]], [[1mco]], [[3na9]], [[3lrs]], [[3mme]], [[3hi5]], [[1vge]], [[3nfs]], [[1ad0]], [[3w9d]], [[4nm4]], [[8fab]], [[1opg]], [[4fnl]], [[4fqh]], [[1om3]], [[1aqk]], [[2hff]], [[2agj]], [[3hc0]], [[3g6a]], [[3dgg]], [[3dif]], [[1b2w]], [[3eyo]], [[3eyq]], [[2aj3]], [[3fzu]], [[3aaz]], [[3gje]], [[5fhb]], [[5fha]], [[5f6i]], [[5f6h]], [[5drw]], [[5d6c]], [[4py7]], [[4ptt]], [[4ob5]] - hFab - human<br /> | + | **[[7fab]], [[1mco]], [[3na9]], [[3lrs]], [[3mme]], [[3hi5]], [[1vge]], [[3nfs]], [[1ad0]], [[3w9d]], [[4nm4]], [[8fab]], [[1opg]], [[4fnl]], [[4fqh]], [[1om3]], [[1aqk]], [[2hff]], [[2agj]], [[3hc0]], [[3g6a]], [[3dgg]], [[3dif]], [[1b2w]], [[3eyo]], [[3eyq]], [[2aj3]], [[3fzu]], [[3aaz]], [[3gje]], [[5fhb]], [[5fha]], [[5f6i]], [[5f6h]], [[5drw]], [[5d6c]], [[4py7]], [[4ptt]], [[4ob5]], [[5szf]], [[5chn]], [[4lkc]], [[4hie]], [[4gxv]] - hFab - human<br /> |
**[[3naa]], [[3nab]], [[3nac]], [[3ncj]], [[3o2v]], [[3hc3]], [[3hc4]] - hFab (mutant)<br /> | **[[3naa]], [[3nab]], [[3nac]], [[3ncj]], [[3o2v]], [[3hc3]], [[3hc4]] - hFab (mutant)<br /> | ||
| - | **[[3i75]], [[1nqb]], [[1f4w]], [[1aif]], [[1ghf]], [[2z91]], [[1ind]], [[3bkc]], [[3bkm]], [[1iy0]], [[3pp3]], [[3pp4]], [[3okm]], [[6fab]], 2hkh]], [[1ay1]], [[1nbv]], [[1qbm]], [[1bbd]], [[1dsf]], [[1gpo]], [[1mnu]], [[1igf]], [[1for]], [[1k6q]], [[1bz7]], [[1dqd]], [[2ipt]], [[2iq9]], [[2iqa]], [[2w60]], [[2w9d]], [[3iu4]], [[1q9k]], [[1q9l]], [[1q9o]], [[2z4q]], [[1cl7 | + | **[[6b0w]], [[6azx]], [[5bk5]], [[5bk3]] - hFab anti-circumsporozoite<br /> |
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| + | **[[3i75]], [[1nqb]], [[1f4w]], [[1aif]], [[1ghf]], [[2z91]], [[1ind]], [[3bkc]], [[3bkm]], [[1iy0]], [[3pp3]], [[3pp4]], [[3okm]], [[6fab]], 2hkh]], [[1ay1]], [[1nbv]], [[1qbm]], [[1bbd]], [[1dsf]], [[1gpo]], [[1mnu]], [[1igf]], [[1for]], [[1k6q]], [[1bz7]], [[1dqd]], [[2ipt]], [[2iq9]], [[2iqa]], [[2w60]], [[2w9d]], [[3iu4]], [[1q9k]], [[1q9l]], [[1q9o]], [[2z4q]], [[1cl7]], [[1cr9]], [[1r24]], [[1gig]], [[1uyw]], [[1cgs]], [[2cgr]], [[1q0x]], [[1ibg]], [[3eo0]], [[2op4]], [[2q76]], [[2ojz]], [[2g60]], [[2dbl]], [[1dbj]], [[1dbk]], [[1dbm]], [[1dba]], [[1mrc]], [[2gcy]], [[1flr]], [[1uz6]], [[1rfd]], [[1t2q]], [[1ggb]], [[1ggc]], [[1bm3]], [[2eh7]], [[2fat]], [[3cfc]], [[1fl3]], [[3cfe]], [[4j1u]], [[4gq9]], [[3qg7]], [[3rvt]], [[3s62]], [[4gay]], [[5mx3]], [[5l88]], [[5i66]], [[5cma]], [[5az2]], [[4z0b]], [[4qth]], [[4poz]], [[5vzr]], [[5lgh]], [[5l9d]], [[5l7x]], [[5h2b]], [[4lci]], [[4k23]] - mFab – mouse<br /> | ||
**[[3eot]], [[2d03]], [[3esv]], [[3et9]] – mFab (mutant)<br /> | **[[3eot]], [[2d03]], [[3esv]], [[3et9]] – mFab (mutant)<br /> | ||
**[[3iy2]], [[3iy3]], [[3iy4]], [[3iy5]], [[3iy6]], [[3iy7]] - mFab – Cryo EM<br /> | **[[3iy2]], [[3iy3]], [[3iy4]], [[3iy5]], [[3iy6]], [[3iy7]] - mFab – Cryo EM<br /> | ||
| - | **[[1jpt]], [[3mxv]], [[2o5x]], [[1ucb]], [[1bbj]], [[1t04]], [[2fgw]], [[1fvd]], [[1fve]] - hmFab <br /> | + | **[[1jpt]], [[3mxv]], [[2o5x]], [[1ucb]], [[1bbj]], [[1t04]], [[2fgw]], [[1fvd]], [[1fve]], [[4kuz]] - hmFab <br /> |
**[[1cqk]] – mFab MAK33 CH3 domain<br /> | **[[1cqk]] – mFab MAK33 CH3 domain<br /> | ||
**[[3mj8]], [[3r06]] – AhFab – Armenian hamster<br /> | **[[3mj8]], [[3r06]] – AhFab – Armenian hamster<br /> | ||
**[[3iy1]], [[1zan]] – raFab – rat<br /> | **[[3iy1]], [[1zan]] – raFab – rat<br /> | ||
**[[4k3e]], [[4k3d]] – bFab – bovine<br /> | **[[4k3e]], [[4k3d]] – bFab – bovine<br /> | ||
| - | **[[4b41 | + | **[[4b41]], [[4m3j]] – LgFab – ''Lama glama''<br /> |
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*Anti-HIV Fab | *Anti-HIV Fab | ||
| - | **[[1rz7]], [[1rz8]], [[1rzf]], [[1rzg]], [[1rzi]], [[3mlj]], [[3mug | + | **[[1rz7]], [[1rz8]], [[1rzf]], [[1rzg]], [[1rzi]], [[3mlj]], [[3mug]], [[3qeh]], [[3ttn]], [[rpi]], [[3tnm]], [[4fz8]], [[4f58]], [[4f57]], [[4f5a]], [[5iie]], [[5dt1]], [[5cey]], [[5cex]], [[5cck]], [[5bzw]], [[5bzd]], [[4rqq]], [[5uy3]], [[4qf1]] - hFab <br /> |
**[[3nz8]], [[3o6k]], [[3ntc]], [[3qeg]] – mFab <br /> | **[[3nz8]], [[3o6k]], [[3ntc]], [[3qeg]] – mFab <br /> | ||
| - | **[[5kg9]] – hmFab | + | **[[5kg9]] – hmFab <br /> |
| - | **[[5dd6]], [[5dd5]], [[5dd3]], [[5dd1]], [[4rfe]], [[4q2z]] – rmFab – rhesus macaque <br /> | + | **[[5dd6]], [[5dd5]], [[5dd3]], [[5dd1]], [[4rfe]], [[4q2z]], [[5t4z]] – rmFab – rhesus macaque <br /> |
*Human Fab: small molecule complex | *Human Fab: small molecule complex | ||
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**[[3o2w]] - hFab 1e9 (mutant) + transition state analog<br /> | **[[3o2w]] - hFab 1e9 (mutant) + transition state analog<br /> | ||
**[[3oau]] – hFab 2g12 (mutant) + mannose<br /> | **[[3oau]] – hFab 2g12 (mutant) + mannose<br /> | ||
| - | **[[4ptu]] – hFab + rhamnose<br /> | + | **[[4ptu]], [[4hih]] – hFab + rhamnose<br /> |
**[[1ikf]] – hFab R45 + cyclosporin<br /> | **[[1ikf]] – hFab R45 + cyclosporin<br /> | ||
**[[3oay]], [[3oaz]], [[3ob0]], [[1zls]], [[1zlu]], [[1zlv]], [[1zlw]] - hFab 2g12 + glycan<br /> | **[[3oay]], [[3oaz]], [[3ob0]], [[1zls]], [[1zlu]], [[1zlv]], [[1zlw]] - hFab 2g12 + glycan<br /> | ||
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**[[1dl7]] - mFab MCPC603 + phosphocholine<br /> | **[[1dl7]] - mFab MCPC603 + phosphocholine<br /> | ||
**[[3cfb]], [[3cfd]], [[2g2r]] – mFab + stilbene hapten<br /> | **[[3cfb]], [[3cfd]], [[2g2r]] – mFab + stilbene hapten<br /> | ||
| + | **[[4kze]], [[4kzd]] – mFab + RNA <br /> | ||
*Other Fab: small molecule complex | *Other Fab: small molecule complex | ||
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**[[2jb5]], [[2jb6]] - hmFab + hapten<br /> | **[[2jb5]], [[2jb6]] - hmFab + hapten<br /> | ||
**[[3eyv]] - hmFab 13G5 (mutant) + hapten<br /> | **[[3eyv]] - hmFab 13G5 (mutant) + hapten<br /> | ||
| - | **[[1i3u]], [[1i3v]] - LgFab + hapten<br /> | ||
*Mouse Fab: peptide complex | *Mouse Fab: peptide complex | ||
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**[[3eys]], [[3eyu]] - mFab + amyloid-β-related peptide<br /> | **[[3eys]], [[3eyu]] - mFab + amyloid-β-related peptide<br /> | ||
**[[3ggw]] – mFab + carbohydrate-mimetic peptide<br /> | **[[3ggw]] – mFab + carbohydrate-mimetic peptide<br /> | ||
| - | **[[3cxd]], [[3dsf]] – mFab + osteopontin peptide<br /> | + | **[[3cxd]], [[3dsf]], [[5x5x]] – mFab + osteopontin peptide<br /> |
**[[2zpk]] – mFab + proteinase-activated receptor peptide<br /> | **[[2zpk]] – mFab + proteinase-activated receptor peptide<br /> | ||
**[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]] - mFab + amyloid peptide<br /> | **[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]] - mFab + amyloid peptide<br /> | ||
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**[[1i8k]] – mFab + EGFR peptide<br /> | **[[1i8k]] – mFab + EGFR peptide<br /> | ||
**[[4gag]], [[4gaj]] – mFab + genome polyprotein peptide<br /> | **[[4gag]], [[4gaj]] – mFab + genome polyprotein peptide<br /> | ||
| + | **[[5nph]] – mFab + hepatitis virus peptide <br /> | ||
| + | **[[5mv4]], [[5mu0]] – mFab + collagen peptide <br /> | ||
*Human Fab: peptide complex | *Human Fab: peptide complex | ||
Revision as of 09:05, 21 March 2018
Updated on 21-March-2018
Humanized mouse antibody (hmFab) is a modified mFab which resembles more hFab.
Broadly neutralizing Fab and Neutralizing Fab are anti-HIV Fab.
Lama antibodies or nanobodies or camelid or VHH are natural single-domain antibodies containing just the heavy chain. scFv is a single chain variable fragment is a fusion protein of the variable regions of the heavy and light chains of immunoglobulin.
