12-oxophytodienoate reductase

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== Function ==
== Function ==
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'''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/11'>12-oxophytodienoate</scene> <span style="color:lime;background-color:black;font-weight:bold;">(green)</span> to 3-oxo-pentenyl-cyclopentane octanoate. The expression of OPR is induced by stimuli like touch, wind, wounding, UV light and detergent. OPR uses the cofactor <scene name='71/710043/Cv/8'>flavin mononucleotide (FMN)</scene> <span style="color:cyan;background-color:black;font-weight:bold;">(cyan)</span> which is reduced by NADPH. <scene name='71/710043/Cv/10'>Click here to see active site</scene>. OPR exhibits self inhibition by dimerization.<ref>PMID:11377202</ref> Three isozymes of OPR are known – OPR1, OPR2, OPR3.<br />
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'''12-oxophytodienoate reductase''' (OPR) catalyzes the conversion of <scene name='71/710043/Cv/11'>12-oxophytodienoate</scene> <span style="color:lime;background-color:black;font-weight:bold;">(green)</span> to 3-oxo-pentenyl-cyclopentane octanoate. The expression of OPR is induced by stimuli like touch, wind, wounding, UV light and detergent. OPR uses the cofactor <scene name='71/710043/Cv/12'>flavin mononucleotide (FMN)</scene> <span style="color:cyan;background-color:black;font-weight:bold;">(cyan)</span> which is reduced by NADPH.
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*<scene name='71/710043/Cv/16'>12-oxophytodienoate binding site</scene>.
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*<scene name='71/710043/Cv/17'>FMN binding site</scene>.
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*<scene name='71/710043/Cv/10'>Click here to see whole active site</scene>.
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OPR exhibits self inhibition by dimerization.<ref>PMID:11377202</ref> Three isozymes of OPR are known – OPR1, OPR2, OPR3.<br />
* OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br />
* OPR1 cleaves olefinic bonds in α,β-unsaturated carbonyls.<br />
* OPR3 cleaves olefinic bonds in cyclic enones.
* OPR3 cleaves olefinic bonds in cyclic enones.

Revision as of 11:53, 21 March 2018

Tomato OPR1 complex with FMN (cyan) and 12-oxophytodienoate (green), (PDB code 1icq)

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3D Structures of 12-oxophytodienoate reductase

Updated on 21-March-2018

References

  1. ↑ Breithaupt C, Strassner J, Breitinger U, Huber R, Macheroux P, Schaller A, Clausen T. X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE. Structure. 2001 May 9;9(5):419-29. PMID:11377202

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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