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Sandbox1qu7
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(Difference between revisions)
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==Serine Chemotaxis== | ==Serine Chemotaxis== | ||
| - | + | The whole structure of<scene name='78/782579/Cartooncylinder/2'> Ser receptor</scene> can be divided into 4 domains: <scene name='78/782579/The_periplasmic/1'>periplasmic</scene>, transmembrane, <scene name='78/782579/Hampdomain/1'>HAMP</scene> and <scene name='78/782579/Cytoplasmic_domain/1'>cytoplasmic domain</scene>. Additionally, there are<scene name='78/782579/Methylation_cites/1'>methylation cites</scene> in the cytoplasmic domain. | |
| - | <Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption=' | + | <Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='This is the whole intact Tsr Receptor with no ligand attached' scene='Insert optional scene name here' /> |
<StructureSection load='1qu7' size='350' side='right' caption='This the structure of Ser Protein which is in the transmembrane domain, this forms a trimer of dimers (PDB entry [[1qu7]])' scene=''> | <StructureSection load='1qu7' size='350' side='right' caption='This the structure of Ser Protein which is in the transmembrane domain, this forms a trimer of dimers (PDB entry [[1qu7]])' scene=''> | ||
== Function == | == Function == | ||
| - | The<scene name='78/782579/Serreceptor/3'> Ser Receptor</scene> is a helical-bundle structure signaling molecule | + | Motile bacteria like Escherichia coli cells are attracted to and repelled by signals in their surroundings due to transmembrane chemoreceptor proteins, i.e: their direction of movement is controlled by this mechanism. The stimulus information travels through the receptor molecule, shifting the dynamic properties of adjoining structural elements. The section of the<scene name='78/782579/Serreceptor/3'> Ser Receptor</scene> found in the cytoplasmic membrane is a helical-bundle structure signaling molecule. |
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== Disease and Relevance == | == Disease and Relevance == | ||
| + | If we can understand how the bacteria moves we might be able to make antibiotics that can target those specific control sites and prevent diseases by halting their search for attractant molecules. | ||
The chemoreceptors Escherichia coli and Salmonella typhimurium are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis. It proposes that strong helix packing stabilizes the receptor. | The chemoreceptors Escherichia coli and Salmonella typhimurium are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis. It proposes that strong helix packing stabilizes the receptor. | ||
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== Overview of Structure and Mechanism == | == Overview of Structure and Mechanism == | ||
| + | The section of the<scene name='78/782579/Serreceptor/3'> Ser Receptor</scene> found in the cytoplasmic membrane is a helical-bundle structure signaling molecule. | ||
== References == | == References == | ||
| - | + | 1)Microbial Translocation: Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update | |
| + | John S. Parkinson, Gerald L. Hazelbauer, and Joseph J. Falke | ||
| + | 2)Multidimensional Solid-State Nuclear Magnetic Resonance of a Functional Multiprotein Chemoreceptor ArrayMichael J. Harris, Jochem O. Struppe, Benjamin J. Wylie, Ann E. McDermott, and Lynmarie K. Thompson* | ||
| + | 3)Engineered Socket Study of Signaling through a Four-Helix Bundle: Evidence for aYin-Yang Mechanism in the Kinase Control Module of the Aspartate ReceptorKalin E. Swain, Miguel A. Gonzalez, and Joseph J. Falke | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:17, 23 March 2018
Serine Chemotaxis
The whole structure of can be divided into 4 domains: , transmembrane, and . Additionally, there are in the cytoplasmic domain.
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