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User:Kyle Burton/Sandbox1

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<Structure load='1b7f' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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<Structure load='1b7f' size='350' frame='true' align='right' caption='Sex-Lethal Protein in ''Drosophila Melanogaster'' ' scene='Insert optional scene name here' />
This is a default text for your page '''Kyle Burton/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page '''Kyle Burton/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.

Revision as of 15:09, 27 March 2018

PDB ID 1b7f

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This is a default text for your page Kyle Burton/Sandbox1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Contents

Background & Significance

Sex Lethal Protein (i.e. Sxl) is a splicing repressor in the male developmental pathway of sex determination of the common fruit fly, Drosophila melanogaster. Sxl regulates alternative splicing pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (Tra) and the male-sex lethal (Msl-2) proteins. Tra is a splicing activator in the female developmental pathway, and Msl2 modulates X chromosome application in male fruit flies. The mechanism for how Sxl targets these pathways differs slightly. In both mechanisms, Sxl occupies the 3' splice site and prevents U2AF from binding. U2AF is a vital splicing factor observed in the male developmental pathway. In Msl-2 targeting, Sxl also blocks another regulatory splicing factor, TIA-1, and the U1 snRNP. Sxl also has the ability to control its own splicing pattern in order to conserve female expression. It does so by surrounding Exon 3 of its own RNA and creating a RNP complex to eliminate this exon. Upon this elimination, Sxl becomes active and female expression is maintained. The structural interactions with regards to the targeting of the 5' splice site and of its own mRNA transcript is much less understood than the competition of Sxl with U2AF at the 3' splice site.


Disease

Relevance

Structural highlights

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</StructureSection>

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Kyle Burton

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