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| - | | + | #REDIRECT [[6cnq]] This PDB entry is obsolete and replaced by 6cnq |
| - | ==MBD2 in complex with methylated DNA==
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| - | <StructureSection load='6c2e' size='340' side='right' caption='[[6c2e]], [[Resolution|resolution]] 2.15Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6c2e]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C2E FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c2e OCA], [http://pdbe.org/6c2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c2e RCSB], [http://www.ebi.ac.uk/pdbsum/6c2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c2e ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Arrowsmith, C H]]
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| - | [[Category: Bountra, C]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Edwards, A M]]
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| - | [[Category: Liu, K]]
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| - | [[Category: Min, J]]
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| - | [[Category: Tempel, W]]
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| - | [[Category: Xu, C]]
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| - | [[Category: Dna binding]]
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| - | [[Category: Dna binding protein-dna complex]]
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| - | [[Category: Dna methylation]]
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| - | [[Category: Sgc]]
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