2g6w
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2g6w |SIZE=350|CAPTION= <scene name='initialview01'>2g6w</scene>, resolution 2.14Å | |PDB= 2g6w |SIZE=350|CAPTION= <scene name='initialview01'>2g6w</scene>, resolution 2.14Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=LLF:(4-{(E)-[(2,2-DIFLUOROETHYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE'>LLF</scene> | + | |LIGAND= <scene name='pdbligand=LLF:(4-{(E)-[(2,2-DIFLUOROETHYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>LLF</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6w OCA], [http://www.ebi.ac.uk/pdbsum/2g6w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g6w RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Alexeev, D.]] | [[Category: Alexeev, D.]] | ||
| - | [[Category: LLF]] | ||
[[Category: 8-amino-7-oxonanoate]] | [[Category: 8-amino-7-oxonanoate]] | ||
[[Category: biotin]] | [[Category: biotin]] | ||
| Line 31: | Line 33: | ||
[[Category: synthase]] | [[Category: synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:40 2008'' |
Revision as of 00:12, 31 March 2008
| |||||||
| , resolution 2.14Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | 8-amino-7-oxononanoate synthase, with EC number 2.3.1.47 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306
Page seeded by OCA on Mon Mar 31 03:12:40 2008
