1urq
From Proteopedia
(Difference between revisions)
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| - | == | + | |
| + | ==Crystal structure of neuronal Q-SNAREs in complex with R-SNARE motif of Tomosyn== | ||
<StructureSection load='1urq' size='340' side='right' caption='[[1urq]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1urq' size='340' side='right' caption='[[1urq]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1urq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1URQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1urq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1URQ FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1br0|1br0]], [[1dn1|1dn1]], [[1ez3|1ez3]], [[1hvv|1hvv]], [[1jth|1jth]], [[1kil|1kil]], [[1n7s|1n7s]], [[1sfc|1sfc]], [[2bu0|2bu0]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1br0|1br0]], [[1dn1|1dn1]], [[1ez3|1ez3]], [[1hvv|1hvv]], [[1jth|1jth]], [[1kil|1kil]], [[1n7s|1n7s]], [[1sfc|1sfc]], [[2bu0|2bu0]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1urq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urq OCA], [http://pdbe.org/1urq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1urq RCSB], [http://www.ebi.ac.uk/pdbsum/1urq PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1urq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1urq OCA], [http://pdbe.org/1urq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1urq RCSB], [http://www.ebi.ac.uk/pdbsum/1urq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1urq ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/SNP25_HUMAN SNP25_HUMAN]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ur/1urq_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ur/1urq_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1urq ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
| - | *[[Flock house virus | + | *[[Flock house virus protein B2|Flock house virus protein B2]] |
*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | *[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]] | ||
== References == | == References == | ||
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[[Category: Pobbati, A]] | [[Category: Pobbati, A]] | ||
[[Category: Razeto, A]] | [[Category: Razeto, A]] | ||
| + | [[Category: Coiled coil]] | ||
[[Category: Exocytosis]] | [[Category: Exocytosis]] | ||
[[Category: Four helical bundle]] | [[Category: Four helical bundle]] | ||
[[Category: Tomosyn-snare complex]] | [[Category: Tomosyn-snare complex]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 08:02, 28 March 2018
Crystal structure of neuronal Q-SNAREs in complex with R-SNARE motif of Tomosyn
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