RecG protein

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(New page: '''RecG''' The RecG protein of Escherichia coli is a Superfamily 2 (SF2) branched-DNA-specific helicase which promotes rescue of damaged replication forks by catalysing their unwinding ...)
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Revision as of 10:35, 29 March 2018

RecG

The RecG protein of Escherichia coli is a Superfamily 2 (SF2) branched-DNA-specific helicase which promotes rescue of damaged replication forks by catalysing their unwinding and conversion to Holliday junctions. A single RecG monomer unwinds two DNA duplexes; the leading strand duplex and the lagging strand duplex and then reanneal the parental and the newly synthetized strands. This mechanism of repair is ATP-dependent and does not require DNA double strand break. RecG works synergistically with the RuvABC repair system[1].

Reference:
  1. ↑ Singleton, M. R., Scaife, S. & Wigley, D. B. Structural analysis of DNA replication fork reversal by RecG. Cell 107, 79–89 (2001)

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Alisa Ferofontov, Michal Harel

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