Botulinum neurotoxin
From Proteopedia
(Difference between revisions)
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**[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[3bon]], [[3qix]], [[2ise]], [[2isg]], [[2ish]], [[4ej5]] - CbCBN LC + Zn<br /> | **[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[3bon]], [[3qix]], [[2ise]], [[2isg]], [[2ish]], [[4ej5]] - CbCBN LC + Zn<br /> | ||
| + | **[[5vgv]] - CbCBN LC + Cu<br /> | ||
| + | **[[5vgx]] - CbCBN LC + Hg<br /> | ||
**[[3bok]] - CbCBN LC <br /> | **[[3bok]] - CbCBN LC <br /> | ||
**[[1e1h]], [[1xtf]], [[4kuf]], [[4el4]], [[4elc]] - CbCBN LC (mutant) + Zn<br /> | **[[1e1h]], [[1xtf]], [[4kuf]], [[4el4]], [[4elc]] - CbCBN LC (mutant) + Zn<br /> | ||
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**[[3dda]], [[3ddb]] - CbCBN LC + synaptosomal-associated protein 25 peptide + Zn<br /> | **[[3dda]], [[3ddb]] - CbCBN LC + synaptosomal-associated protein 25 peptide + Zn<br /> | ||
**[[3zur]], [[3zus]] - CbCBN LC/synaptosomal-associated protein 25 translocation domain<br /> | **[[3zur]], [[3zus]] - CbCBN LC/synaptosomal-associated protein 25 translocation domain<br /> | ||
| - | **[[2g7n]], [[2ilp]], [[2imb]], [[3qiy]], [[3qiz]], [[3qj0]], [[4hev]], [[2ima]] – CbCBN LC + inhibitor + Zn<br /> | + | **[[2g7n]], [[2ilp]], [[2imb]], [[3qiy]], [[3qiz]], [[3qj0]], [[4hev]], [[2ima]], [[5v8r]] – CbCBN LC + inhibitor + Zn<br /> |
**[[3c88]], [[3c89]], [[3c8a]], [[3c8b]], [[3boo]], [[3qw5]], [[3qw6]], [[3qw7]], [[3qw8]], [[3nf3]] – CbCBN LC + inhibitor peptide + Zn<br /> | **[[3c88]], [[3c89]], [[3c8a]], [[3c8b]], [[3boo]], [[3qw5]], [[3qw6]], [[3qw7]], [[3qw8]], [[3nf3]] – CbCBN LC + inhibitor peptide + Zn<br /> | ||
| - | **[[4ks6]], [[4ktx]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br /> | + | **[[4ks6]], [[4ktx]], [[5v8p]], [[5v8u]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br /> |
**[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br /> | **[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br /> | ||
**[[3k3q]] - CbCBN LC + antibody + Zn<br /> | **[[3k3q]] - CbCBN LC + antibody + Zn<br /> | ||
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*Type A receptor-binding domain | *Type A receptor-binding domain | ||
| - | **[[2vua]], [[3fuo]], [[5tpb]], [[5tpc]] – CbPBN <br /> | + | **[[2vua]], [[3fuo]], [[5tpb]], [[5tpc]], [[5lr0]], [[5mk6]], [[5mk7]] – CbPBN <br /> |
**[[4iqp]] – CbPBN (mutant)<br /> | **[[4iqp]] – CbPBN (mutant)<br /> | ||
**[[2vu9]] – CbPBN + polysaccharide + Mg<br /> | **[[2vu9]] – CbPBN + polysaccharide + Mg<br /> | ||
| - | **[[4jra]], [[5jlv]] – CbCBN + synaptic vesicle glycoprotein 2C<br /> | + | **[[4jra]], [[5jlv]], [[5moy]] – CbCBN + synaptic vesicle glycoprotein 2C<br /> |
**[[5jmc]] – CbCBN (mutant) + synaptic vesicle glycoprotein 2C<br /> | **[[5jmc]] – CbCBN (mutant) + synaptic vesicle glycoprotein 2C<br /> | ||
**[[4zjx]] – CbCBN + polypeptide inhibitor<br /> | **[[4zjx]] – CbCBN + polypeptide inhibitor<br /> | ||
| + | **[[5l21]] – CbCBN + VHH-C2<br /> | ||
*Type A Light+Heavy Chain translocation domain | *Type A Light+Heavy Chain translocation domain | ||
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**[[2nm1]], [[4kbb]] - CbCBN + synaptotagmin-2 peptide<br /> | **[[2nm1]], [[4kbb]] - CbCBN + synaptotagmin-2 peptide<br /> | ||
**[[1z0h]] – CbCBN <br /> | **[[1z0h]] – CbCBN <br /> | ||
| + | **[[5vid]] – CbCBN + mini-protein binder<br /> | ||
*Type C Light Chain | *Type C Light Chain | ||
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**[[2vxr]], [[3mpp]] - CbCBN <br /> | **[[2vxr]], [[3mpp]] - CbCBN <br /> | ||
| + | |||
| + | *Type X Light Chain | ||
| + | |||
| + | **[[6f4e]] - CbCBN LC<br /> | ||
| + | **[[6f47]] - CbCBN LC + Zn<br /> | ||
}} | }} | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 10:12, 2 April 2018
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3D structures of botulinum neurotoxin
Updated on 02-April-2018
References
- ↑ Montecucco C, Molgo J. Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. PMID:15907915 doi:http://dx.doi.org/10.1016/j.coph.2004.12.006
- ↑ Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:9783750 doi:10.1038/2338
