Vpr protein

From Proteopedia

Revision as of 19:02, 2 April 2018

spinqualitylabelsall models HIV-1 Vpr protein (cyan) complex with Human DNA damage-binding protein (grey), VPRBP (pink) and Uracyl-DNA glycosylase (yellow) (PDB code 5jk7) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Vpr protein (Vpr) or viral protein R is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 (HIV-1). Vpr has several roles in the progression of HIV-1 disease, including regulation the HIV-1 pre-integration complex nuclear import and virus replication in non-dividing macrophages[1]. For details see HIV and accessory proteins.

3D Structures of Vpr protein

Updated on 02-April-2018

1m8l – Vpr - NMR - HIV-1
1esx - synthetic Vpr - NMR - HIV-1
5jk7 – Vpr + DDB1 + DCAF-1 + UNG2 – X-ray solution - HIV-1
1x9v – Dimeric structure of the Vpr C-terminal domain - NMR
1vpc - C-terminal domain of Vpr - NMR - HIV-1
1fi0 - Vpr residues 13-33 in micelles - NMR - HIV-1
1bde - NMR solution of Vpr peptides connected to cell cycle arrest and nuclear provirus transfer
5b56 - Importin subunit alpha-1 + Vpr C-terminal domain - crystallographic analysis
1kzs, 1kzt, 1kzv - Vpr residues 34-51 - NMR - HIV-1
1dsj - Vpr residues 50-75 - NMR - HIV-1
1ceu - Vpr N-terminal domain - NMR - HIV-1
1dsk - Vpr residues 59-86 - NMR - HIV-1
4u1s - HLA-I + Beta-2-microglobulin + Vpr protein - X-ray diffraction

References

1. ↑ Bukrinsky M, Adzhubei A. Viral protein R of HIV-1. Rev Med Virol. 1999 Jan-Mar;9(1):39-49. PMID:10371671