2gcz
From Proteopedia
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|PDB= 2gcz |SIZE=350|CAPTION= <scene name='initialview01'>2gcz</scene> | |PDB= 2gcz |SIZE=350|CAPTION= <scene name='initialview01'>2gcz</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcz OCA], [http://www.ebi.ac.uk/pdbsum/2gcz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gcz RCSB]</span> | ||
}} | }} | ||
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[[Category: McIntosh, J M.]] | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B M.]] | [[Category: Olivera, B M.]] | ||
| - | [[Category: NH2]] | ||
[[Category: alpha-helix]] | [[Category: alpha-helix]] | ||
[[Category: beta-turn]] | [[Category: beta-turn]] | ||
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[[Category: two disulfide bond]] | [[Category: two disulfide bond]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:14:59 2008'' |
Revision as of 00:15, 31 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of alpha-Conotoxin OmIA
Overview
alpha-Conotoxin OmIA from Conus omaria is the only alpha-conotoxin that shows a approximately 20-fold higher affinity to the alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy. alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5)-Asn(12) forming an alpha-helix. Structural features of alpha-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.
About this Structure
2GCZ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. Epub 2006 Apr 27. PMID:16678128
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