2gcs

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|PDB= 2gcs |SIZE=350|CAPTION= <scene name='initialview01'>2gcs</scene>, resolution 2.10&Aring;
|PDB= 2gcs |SIZE=350|CAPTION= <scene name='initialview01'>2gcs</scene>, resolution 2.10&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|LIGAND= <scene name='pdbligand=2AD:2&#39;-AMINO-2&#39;-DEOXYADENOSINE'>2AD</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=A23:ADENOSINE-5&#39;-PHOSPHATE-2&#39;,3&#39;-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
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|RELATEDENTRY=[[2gcv|2GCV]], [[2h0s|2H0S]], [[2h0w|2H0W]], [[2h0x|2H0X]], [[2h0z|2H0Z]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcs OCA], [http://www.ebi.ac.uk/pdbsum/2gcs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gcs RCSB]</span>
}}
}}
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[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Klein, D J.]]
[[Category: Klein, D J.]]
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[[Category: MG]]
+
[[Category: helix]]
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[[Category: rna; ribozyme; pseudoknot; helix]]
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[[Category: pseudoknot]]
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[[Category: ribozyme]]
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[[Category: rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:03:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:15:06 2008''

Revision as of 00:15, 31 March 2008

Image:2gcs.gif


PDB ID 2gcs

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: , , , , , ,
Related: 2GCV, 2H0S, 2H0W, 2H0X, 2H0Z


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme


Overview

The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.

About this Structure

2GCS is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543

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