From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[6fxn]] This PDB entry is obsolete and replaced by 6fxn |
| - | ==Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab==
| + | |
| - | <StructureSection load='6erx' size='340' side='right' caption='[[6erx]], [[Resolution|resolution]] 2.90Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[6erx]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERX FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6erx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erx OCA], [http://pdbe.org/6erx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6erx RCSB], [http://www.ebi.ac.uk/pdbsum/6erx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6erx ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Jiang, X]]
| + | |
| - | [[Category: Lammens, A]]
| + | |
| - | [[Category: Maskos, K]]
| + | |
| - | [[Category: Schneider, P]]
| + | |
| - | [[Category: Willen, L]]
| + | |
| - | [[Category: Antibody]]
| + | |
| - | [[Category: B cell]]
| + | |
| - | [[Category: Baff]]
| + | |
| - | [[Category: Cytokine]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Immunology]]
| + | |
| - | [[Category: Protero]]
| + | |
Current revision
- REDIRECT 6fxn This PDB entry is obsolete and replaced by 6fxn
