5ud7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Wild-Type Ig-like Domain== | |
| - | + | <StructureSection load='5ud7' size='340' side='right' caption='[[5ud7]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ud7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UD7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ud7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ud7 OCA], [http://pdbe.org/5ud7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ud7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ud7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ud7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] Progressive non-fluent aphasia;Amyotrophic lateral sclerosis;Nasu-Hakola disease;Semantic dementia;Behavioral variant of frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.<ref>PMID:10799849</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Min, X]] | [[Category: Min, X]] | ||
[[Category: Sudom, A]] | [[Category: Sudom, A]] | ||
[[Category: Wang, Z]] | [[Category: Wang, Z]] | ||
| + | [[Category: Ig-like domain]] | ||
| + | [[Category: Immunoregulatory]] | ||
| + | [[Category: Lipid binding]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 05:52, 4 April 2018
Crystal Structure of Wild-Type Ig-like Domain
| |||||||||||
